Dr. Fries was one of Gothcorp's most brilliant scientists and cryogenic researchers, however he was unable to cure his wife Nora of a deadly disease. His research in cryogenics was eventually cut off by the bureaucrats at Gothcorp. His experiment to create a cryogenic freezing chamber to house his wife until a cure could be found was interrupted by Ferris Boyle, C.E.O. of Gothcorp, and his security guards. A fight ensued, accompanied by an explosion. In the explosion, Dr.Fries was smashed into his cryogenic freezing tanks. The accident soaked Dr. Fries's entire body with the freezing solution and rendered him unable to survive outside of a sub-zero environment. He vowed revenge on those who had wronged him.
This change also caused brain damage, making him quite insane. Victor was forced to create a vacuum tight suit which maintained his body temperature at 50 degrees below zero. He also enabled the suit's cybernetic processor to increase his strength and generate intense fields of cold and so.... Mr. Freeze was born.