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The Empire of America is the largest Imperial empire on the planet. Although it is declining in its standing in the world, it is an international center for politics, theater, music, fashion, finance, and culture. It once boasted a large number of nations under its direct control, inspiring the motto “The sun never sets on the American Empire.”

The Empire of America is technically a constitutional monarchy, led by King Jefferson VI, with a parliamentary democracy, led by Prime Minister Jonathan Vincent Horne, comprising fifty states and a federal district. In reality, it is the Crime Syndicate that holds the true power in the Empire. The Crime Syndicate consists of six families, led by Ultraman, Owlman, Superwoman, J'edd J'arkus, Power Ring, and The Quick. Fashioned after a mafia, each family head has their own group of trusted lieutenants called Made Men, employ thousands of criminals, and conduct their enterprises in designated territories. They rule the Empire, and much of their Earth, through fear. For years, they ran rampant and did whatever they chose without opposition. On occasion, the Syndicate would turn their powers on the people and remind them of their fragile existence. Routine meetings of the family heads are conducted in the organization's secret lunar base, the Panopticon. The government and other civil authorities do nothing in order to retain the illusion of minimal order. Several of the governments have stockpiles of nuclear warheads, the one thing capable of stopping the Syndicate, but the resulting devastation from their usage would also take innocent lives.

Only a few thing prevent the Crime Syndicate’s complete domination of America, one of them being the Revengers, Negative-Earth’s Mightiest Black-Ops. Led by Lt. America, the team’s purpose is to protect the King and Parliament from both domestic and extraterrestrial threats. The Kingdom uses the Revengers to perform surgical strikes against the Syndicate, as well as other targets, to keep their power in check. The Revengers have main operations under the Black House in Washington D.C.

The Agents of H.A.T.E. (Headquarters of Active Terrorist Effort) is an international terrorist and criminal agency controlled by a Shadow Government Cabal. They are lead by a director, currently former spy and solider Nick Fury, who reports to the Shadow Council made up of members from various people of power. Founded to destabilize nations and to combat technologically advanced threats on the Shadow Government‘s security. Throughout the years, they remained on the front lines fighting freedom, extraterrestrial menaces, and act as an international secret police. While most of their operations are mobile and global, it is rumored they have a large base of operations somewhere in the Rocky Mountains.

Due to a sudden leap in evolution, Freaks, or Homo degenerate, are born with superhuman abilities which generally manifest themselves at puberty. Freaks are often hated and feared by other humans because they are different from themselves. The Geno-Men (G-Men) is a group dedicated to the cause of freak superiority over humans. Throughout its various incarnations, the G-Men's agenda gravitated towards either subjugating the human race to the will of freaks or eradicating humanity altogether. They are most often opposed by The Brotherhood, a security force created to harbor peace between the emerging freak population and baseline humans. The G-Men have their lair at mansion of their founder and leader, Dr. Niles “Chief” Caulder, just outside of Detroit.

While trying to attack Negative-Earth with the extra-dimensional, demonic beings called the Undying Ones, the rouge sorcerer Mr. Strange manipulated Sea King into aiding him, and then teamed with the monstrous Doc Samson to help the demons. Only the Negative Zone’s Sorcerer Supreme, Baron Mordo was able to thwart them. Later, when the Yannian scientist Yandroth menaced Negative-Earth with the Alphatron doomsday device, Mr. Strange persuaded an eager Samson and Sea King to help him assist Yandroth's scheme, forming the "non-team" known as the Offenders.

Finally, The Fearsome Four are a group of intellectual property thieves and science plunders lead by Reed Richards (The Brute). After the team gained powers during a botched theft of an experimental spacecraft; Susan Storm (Malice), Johnny Storm (Ooze) and pilot Ben Grimm (The Unseeable) were forced to remain together and exploit the boundaries of science. Based out of the Baxter Building, the group are funded by Richards’ personal fortune accumulated by the many patents he has stolen. The teams exploits, and turf war with the Crime Syndicate and Revengers, has made them infamous worldwide and beyond.