This is a pretty simple and easy guide to dealing with characters taken over by Venom (or any other symbiote, although, you might have to adjust depending on which symbiote it is.)
Venom-izing Guide:
F: +2CS
A: +1CS
S: +2CS
E: +3CS
R: -1CS
I: +0CS
P: -1CS
New Talents: Wrestling
New Powers:
Spider Sense immunity: Characters with Spider-Sense or another similar power will not be able to use their power to sense the Venom-ized character’s attacks attacks.
Body Resistance: The symbiote provides Good protection from blunt attacks.
Camouflage: +2CS when blindsiding.
New Weakness:
High-Pitched Sounds: If particularly high-pitched sounds occur within 3 areas, the Venom-ized character must roll a Psyche feat and get yellow or above. If they fail, they are stunned for every round the sound is playing. If they succeed, they are able to move 1 area per round. No matter what, if the sound continues for three rounds, Venom is ripped off the host’s body completely, taking away all effects.
Fire: If fire touches the Venom-ized character, they are knocked prone two rounds. If they stay in the fire up to that point, the symbiote is taken off the character, and if it stays in the fire for another two rounds, it can be damaged or destroyed to the GM’s discretion.
Health Drain: Unless the host is considered “perfect” for Venom or the un-adjusted Strength is above Incredible, the host’s health is drained by 20 every round.
Emotional Control: Any and all of the negative emotions the host experienced while Venom-ized will be tripled, causing their Psyche drop to the GM’s discretion.
Resources and Popularity drop: Once Venom-ized, the character’s Resources will be affected by a -2CS. The Popularity will drop by 20.